| Total | 36,017 | 973 | 347 | 14 |
|---|---|---|---|---|
| County | Cases | New Cases | Deaths | New Deaths |
| Minnehaha | 9,701 | + 264 | 100 | + 3 |
| Pennington | 3,835 | + 93 | 47 | + 2 |
| Lincoln | 2,383 | + 70 | 16 | |
| Brown | 1,854 | + 31 | 4 | |
| Codington | 1,325 | + 29 | 10 | |
| Brookings | 1,258 | + 16 | 4 | + 2 |
| Beadle | 1,121 | + 27 | 13 | |
| Meade | 847 | + 21 | 9 | |
| Davison | 770 | + 17 | 5 | + 1 |
| Hughes | 766 | + 16 | 5 | |
| Lawrence | 746 | + 36 | 6 | + 1 |
| Clay | 735 | + 11 | 8 | |
| Oglala Lakota | 710 | + 58 | 5 | |
| Union | 686 | + 13 | 10 | |
| Yankton | 681 | + 29 | 5 | |
| Turner | 413 | + 14 | 8 | |
| Todd | 381 | + 24 | 5 | |
| Bon Homme | 354 | + 22 | 1 | |
| Charles Mix | 332 | + 12 | 0 | |
| Lake | 320 | + 6 | 8 | |
| Roberts | 301 | + 5 | 4 | |
| Custer | 288 | + 5 | 3 | |
| Grant | 278 | + 5 | 2 | |
| Dewey | 277 | + 1 | 0 | |
| Butte | 261 | + 13 | 3 | |
| Walworth | 257 | + 3 | 2 | + 1 |
| Tripp | 249 | + 7 | 2 | + 1 |
| Brule | 243 | + 15 | 2 | |
| Spink | 232 | + 5 | 1 | |
| Lyman | 220 | + 7 | 5 | + 1 |
| Buffalo | 218 | + 5 | 4 | |
| Hutchinson | 200 | + 1 | 2 | |
| McCook | 192 | + 4 | 1 | |
| Gregory | 192 | + 6 | 9 | + 1 |
| Faulk | 189 | + 7 | 1 | |
| Moody | 183 | + 4 | 2 | |
| Fall River | 178 | + 5 | 6 | |
| Hamlin | 173 | + 7 | 0 | |
| Aurora | 159 | 0 | ||
| Deuel | 159 | + 2 | 0 | |
| Jerauld | 154 | 6 | ||
| Douglas | 154 | + 3 | 4 | |
| Kingsbury | 151 | + 2 | 2 | |
| Day | 145 | + 4 | 2 | + 1 |
| Corson | 143 | + 4 | 1 | |
| Bennett | 143 | + 7 | 5 | |
| Edmunds | 127 | + 1 | 1 | |
| Miner | 121 | 1 | ||
| Jackson | 100 | + 6 | 1 | |
| Hand | 95 | + 2 | 1 | |
| Clark | 88 | + 7 | 0 | |
| Potter | 88 | + 1 | 0 | |
| Ziebach | 82 | + 1 | 1 | |
| Stanley | 78 | + 2 | 0 | |
| Sanborn | 75 | + 1 | 0 | |
| Haakon | 73 | + 3 | 1 | |
| Hanson | 72 | + 4 | 1 | |
| Campbell | 71 | -1 | 0 | |
| Perkins | 69 | + 2 | 0 | |
| McPherson | 61 | + 2 | 0 | |
| Marshall | 60 | 1 | ||
| Mellette | 58 | + 4 | 1 | |
| Sully | 39 | 0 | ||
| Harding | 39 | + 1 | 0 | |
| Hyde | 37 | + 2 | 0 | |
| Jones | 27 | -1 | 0 | |
| Unassigned | 0 | 0 |